Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2022/09/03 17:30 | Mount Union v Defiance Yellow Jackets | L | 65-0 |
| NCAAF | 2021/11/13 18:30 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 |
| NCAAF | 2021/11/06 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 |
| NCAAF | 2021/10/30 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 |
| NCAAF | 2022/09/10 17:00 | Kalamazoo Hornets v Kenyon Lords | W | 24-21 |
| NCAAF | 2022/09/03 17:00 | Kalamazoo Hornets v Oberlin Yeomen | W | 21-14 |
| NCAAF | 2021/11/13 18:00 | Kalamazoo Hornets v Adrian Bulldogs | L | 21-33 |
| NCAAF | 2021/10/30 17:00 | Olivet Comets v Kalamazoo Hornets | L | 49-7 |
| NCAAF | 2021/10/23 17:00 | Trine Thunder v Kalamazoo Hornets | L | 47-13 |
| NCAAF | 2021/10/16 17:00 | Kalamazoo Hornets v Albion Britons | L | 0-49 |
| NCAAF | 2021/10/09 17:00 | Kalamazoo Hornets v Alma College Scots | L | 3-28 |
| NCAAF | 2021/10/02 17:00 | Hope Flying Dutchmen v Kalamazoo Hornets | L | 67-0 |