Stadium: Panther Stadium Round: 1
| NCAAF | 2021/09/18 17:00 | William Jewell College Cardinals v Ohio Dominican Panthers | W | 25-35 |
| NCAAF | 2022/09/10 17:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 28-13 |
| NCAAF | 2022/09/03 16:00 | Ohio Dominican Panthers v Findlay Oilers | W | 28-14 |
| NCAAF | 2021/11/13 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | L | 21-17 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 34-21 |
| NCAAF | 2021/10/23 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 56-17 |
| NCAAF | 2021/10/16 16:00 | Ohio Dominican Panthers v Findlay Oilers | L | 14-21 |
| NCAAF | 2021/10/09 23:00 | Ashland Eagles v Ohio Dominican Panthers | W | 24-34 |
| NCAAF | 2022/09/10 17:00 | Black Hills State v William Jewell College Cardinals | L | 38-19 |
| NCAAF | 2022/09/02 00:00 | William Jewell College Cardinals v Colorado Mesa University Mavericks | L | 14-37 |
| NCAAF | 2021/11/13 19:00 | William Jewell College Cardinals v Quincy | L | 17-51 |
| NCAAF | 2021/11/06 18:00 | Indianapolis Greyhounds v William Jewell College Cardinals | L | 45-14 |
| NCAAF | 2021/10/30 18:00 | William Jewell College Cardinals v Lindenwood | L | 10-53 |
| NCAAF | 2021/10/23 19:00 | Truman Bulldogs v William Jewell College Cardinals | L | 52-0 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | L | 37-16 |
| NCAAF | 2021/10/09 20:00 | William Jewell College Cardinals v Southwest Baptist University Bearcats | L | 10-55 |