Stadium: First Security Stadium Round: 1
| NCAAF | 2021/09/18 23:00 | Southern Arkansas Muleriders v Harding Bisons | W | 6-37 |
| NCAAF | 2019/09/21 23:00 | Southern Arkansas Muleriders v Harding Bisons | W | 0-31 |
| NCAAF | 2022/09/11 00:00 | Harding Bisons v Southeastern Oklahoma State Savage Storm | W | 38-13 |
| NCAAF | 2022/09/01 23:00 | East Central Tigers v Harding Bisons | W | 12-29 |
| NCAAF | 2021/11/27 19:00 | Harding Bisons v NW Missouri State | L | 9-28 |
| NCAAF | 2021/11/20 19:00 | Harding Bisons v Washburn Ichabods Football | W | 30-14 |
| NCAAF | 2021/11/13 20:00 | Arkansas Tech Wonder Boys v Harding Bisons | W | 0-31 |
| NCAAF | 2021/11/06 19:00 | Southwestern Oklahoma State Bulldogs v Harding Bisons | W | 7-55 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding Bisons | W | 14-73 |
| NCAAF | 2021/10/23 20:00 | Harding Bisons v Arkansas Monticello Boll Weevils | W | 64-7 |
| NCAAF | 2022/09/10 23:00 | Southwestern Oklahoma State Bulldogs v Southern Arkansas Muleriders | L | 24-20 |
| NCAAF | 2022/09/01 23:00 | Southern Arkansas Muleriders v Northwestern Oklahoma State Rangers | W | 62-31 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |