Stadium: Schmidt Stadium Round: 1
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | W | 21-48 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 |
| NCAAF | 2021/10/30 17:00 | Lycoming Warriors v Wilkes Colonels | L | 30-27 |
| NCAAF | 2021/10/23 17:00 | Wilkes Colonels v Lebanon Valley Flying Dutchmen | W | 30-20 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | L | 30-13 |
| NCAAF | 2021/10/09 16:00 | Albright Lions v Wilkes Colonels | W | 28-31 |
| NCAAF | 2021/10/02 16:00 | Wilkes Colonels v Stevenson Mustangs | W | 21-14 |
| NCAAF | 2022/09/10 17:00 | Hampden Sydney Tigers v Widener Pride | W | 27-31 |
| NCAAF | 2022/09/03 17:00 | Widener Pride v Rowan Profs | L | 20-42 |
| NCAAF | 2021/11/13 17:00 | Delaware Valley Aggies v Widener Pride | L | 27-0 |
| NCAAF | 2021/11/06 17:00 | Widener Pride v Lycoming Warriors | W | 17-0 |
| NCAAF | 2021/10/23 17:00 | Stevenson Mustangs v Widener Pride | L | 29-24 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | W | 30-13 |
| NCAAF | 2021/10/09 16:00 | Alvernia Golden Wolves v Widener Pride | W | 7-37 |
| NCAAF | 2021/10/02 17:00 | Widener Pride v Fdu Florham Devils | L | 3-27 |