Stadium: Francis Field Round: 1
| NCAAF | 2022/09/10 18:00 | Greenville Panthers v Rockford Regents | W | 40-30 |
| NCAAF | 2022/09/03 18:00 | Millikin Big Blue v Greenville Panthers | L | 28-14 |
| NCAAF | 2021/11/20 18:00 | UW-Whitewater v Greenville Panthers | L | 69-7 |
| NCAAF | 2021/11/13 18:00 | Greenville Panthers v Minnesota Morris Cougars | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Finlandia Lions v Greenville Panthers | W | 2-28 |
| NCAAF | 2021/10/30 18:00 | Greenville Panthers v Crown Storm | W | 55-30 |
| NCAAF | 2021/10/16 18:00 | Westminster Blue Jays v Greenville Panthers | W | 14-42 |
| NCAAF | 2021/10/09 17:00 | Greenville Panthers v Northwestern Eagles | W | 35-23 |
| NCAAF | 2022/09/10 22:00 | Alma College Scots v Manchester Spartans | L | 49-7 |
| NCAAF | 2022/09/03 23:00 | North Park Vikings v Manchester Spartans | W | 14-23 |
| NCAAF | 2021/11/13 18:30 | Manchester Spartans v Anderson Ravens | W | 3-0 |
| NCAAF | 2021/11/06 17:30 | Bluffton Beavers v Manchester Spartans | L | 31-7 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |