Stadium: Carl W. Burt Memorial Stadium Round: 1
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2019/10/12 17:30 | Manchester Spartans v Mount St. Joseph Lions | L | 14-47 |
| NCAAF | 2018/10/06 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 49-27 |
| NCAAF | 2022/09/17 18:00 | Greenville Panthers v Manchester Spartans | L | 49-22 |
| NCAAF | 2022/09/10 22:00 | Alma College Scots v Manchester Spartans | L | 49-7 |
| NCAAF | 2022/09/03 23:00 | North Park Vikings v Manchester Spartans | W | 14-23 |
| NCAAF | 2021/11/13 18:30 | Manchester Spartans v Anderson Ravens | W | 3-0 |
| NCAAF | 2021/11/06 17:30 | Bluffton Beavers v Manchester Spartans | L | 31-7 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2022/09/17 17:30 | Mount St. Joseph Lions v Hope Flying Dutchmen | W | 33-28 |
| NCAAF | 2022/09/10 16:00 | Alfred Saxons v Mount St. Joseph Lions | W | 37-43 |
| NCAAF | 2022/09/03 17:30 | Mount St. Joseph Lions v Baldwin Wallace Yellow Jackets | W | 31-28 |
| NCAAF | 2021/11/13 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | L | 58-21 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | W | 23-6 |
| NCAAF | 2021/10/30 17:30 | Mount St. Joseph Lions v Anderson Ravens | W | 35-18 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | W | 28-0 |