Stadium: Dave Wolk Stadium Round: 1
| NCAAF | 2022/09/17 18:00 | Norwich Cadets v Castleton Spartans | L | 26-21 |
| NCAAF | 2022/09/10 18:00 | Castleton Spartans v Fitchburg State Falcons | W | 48-0 |
| NCAAF | 2022/09/03 16:00 | Plymouth State Panthers v Castleton Spartans | L | 20-7 |
| NCAAF | 2021/11/13 17:00 | Castleton Spartans v Gallaudet Bison | W | 31-30 |
| NCAAF | 2021/11/06 16:00 | Alfred State Pioneers v Castleton Spartans | L | 35-24 |
| NCAAF | 2021/10/30 18:00 | Castleton Spartans v Anna Maria Amcats | W | 38-31 |
| NCAAF | 2021/10/23 16:00 | Castleton Spartans v Keystone Giants | W | 41-0 |
| NCAAF | 2021/10/09 16:00 | Dean Bulldogs v Castleton Spartans | W | 13-21 |
| NCAAF | 2022/09/16 23:00 | St Lawrence Saints v Morrisville State Mustangs | L | 15-17 |
| NCAAF | 2022/09/10 16:00 | Norwich Cadets v St Lawrence Saints | W | 19-30 |
| NCAAF | 2022/09/03 16:00 | St Lawrence Saints v Endicott Gulls | L | 0-27 |
| NCAAF | 2021/11/13 17:00 | Buffalo State Bengals v St Lawrence Saints | W | 6-41 |
| NCAAF | 2021/11/06 17:00 | St Lawrence Saints v Rpi Engineers | L | 20-22 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | W | 34-10 |
| NCAAF | 2021/10/23 17:00 | Hobart Statesmen v St Lawrence Saints | L | 17-13 |
| NCAAF | 2021/10/16 17:00 | St Lawrence Saints v Ithaca Bombers | L | 0-17 |