Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2019/10/12 17:30 | Defiance Yellow Jackets v Hanover | L | 0-42 |
| NCAAF | 2018/10/13 17:30 | Hanover v Defiance Yellow Jackets | L | 48-7 |
| NCAAF | 2022/09/24 16:00 | Alfred State Pioneers v Defiance Yellow Jackets | L | 42-33 |
| NCAAF | 2022/09/17 17:30 | Defiance Yellow Jackets v Kalamazoo Hornets | L | 23-42 |
| NCAAF | 2022/09/03 17:30 | Mount Union v Defiance Yellow Jackets | L | 65-0 |
| NCAAF | 2021/11/13 18:30 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 |
| NCAAF | 2021/11/06 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 |
| NCAAF | 2021/10/30 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2022/09/17 17:00 | Hanover v Olivet Comets | L | 28-31 |
| NCAAF | 2022/09/10 17:00 | Adrian Bulldogs v Hanover | L | 33-0 |
| NCAAF | 2022/09/03 17:00 | Hanover v Centre Colonels | L | 29-31 |
| NCAAF | 2021/11/13 18:30 | Hanover v Franklin College Grizzlies | L | 16-27 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | L | 23-6 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | W | 33-0 |
| NCAAF | 2021/10/23 17:30 | Bluffton Beavers v Hanover | W | 10-41 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | W | 51-0 |