Stadium: William H. Greene Stadium Round: 1
| NCAAF | 2022/09/17 17:00 | Ohio Dominican Panthers v William Jewell College Cardinals | L | 31-21 |
| NCAAF | 2022/09/10 17:00 | Black Hills State v William Jewell College Cardinals | L | 38-19 |
| NCAAF | 2022/09/02 00:00 | William Jewell College Cardinals v Colorado Mesa University Mavericks | L | 14-37 |
| NCAAF | 2021/11/13 19:00 | William Jewell College Cardinals v Quincy | L | 17-51 |
| NCAAF | 2021/11/06 18:00 | Indianapolis Greyhounds v William Jewell College Cardinals | L | 45-14 |
| NCAAF | 2021/10/30 18:00 | William Jewell College Cardinals v Lindenwood | L | 10-53 |
| NCAAF | 2021/10/23 19:00 | Truman Bulldogs v William Jewell College Cardinals | L | 52-0 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | L | 37-16 |
| NCAAF | 2022/09/18 00:00 | Kentucky Wesleyan v Missouri S&t Miners | W | 11-6 |
| NCAAF | 2022/09/11 00:00 | Kentucky Wesleyan v Lake Erie | L | 21-26 |
| NCAAF | 2022/09/03 17:00 | Northwood Timberwolves v Kentucky Wesleyan | L | 55-13 |
| NCAAF | 2021/11/13 18:00 | Kentucky Wesleyan v Ashland Eagles | L | 0-17 |
| NCAAF | 2021/11/06 17:00 | Hillsdale Chargers v Kentucky Wesleyan | L | 31-12 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | L | 38-28 |
| NCAAF | 2021/10/23 16:00 | Kentucky Wesleyan v Tiffin Dragons | L | 28-34 |
| NCAAF | 2021/10/16 17:00 | Walsh U. Cavaliers v Kentucky Wesleyan | W | 13-23 |