Stadium: Wilkins Stadium Round: 1
| NCAAF | 2021/09/25 23:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 56-49 |
| NCAAF | 2019/11/09 20:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 38-31 |
| NCAAF | 2018/10/27 19:00 | Southern Arkansas Muleriders v Henderson State Reddies | W | 34-14 |
| NCAAF | 2022/09/17 23:00 | Harding Bisons v Southern Arkansas Muleriders | L | 37-17 |
| NCAAF | 2022/09/10 23:00 | Southwestern Oklahoma State Bulldogs v Southern Arkansas Muleriders | L | 24-20 |
| NCAAF | 2022/09/01 23:00 | Southern Arkansas Muleriders v Northwestern Oklahoma State Rangers | W | 62-31 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2022/09/17 23:00 | Henderson State Reddies v Arkansas Monticello Boll Weevils | W | 37-27 |
| NCAAF | 2022/09/10 23:00 | Northwestern Oklahoma State Rangers v Henderson State Reddies | W | 27-51 |
| NCAAF | 2022/09/02 00:00 | Henderson State Reddies v Southwestern Oklahoma State Bulldogs | W | 30-13 |
| NCAAF | 2021/11/13 19:00 | Ouachita Baptist Tigers v Henderson State Reddies | L | 31-28 |
| NCAAF | 2021/11/06 19:00 | Oklahoma Baptist Bison v Henderson State Reddies | W | 34-36 |
| NCAAF | 2021/10/30 19:00 | Henderson State Reddies v Southern Nazarene | W | 34-3 |
| NCAAF | 2021/10/23 19:00 | Arkansas Tech Wonder Boys v Henderson State Reddies | W | 38-41 |
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding Bisons | L | 21-46 |