Stadium: Sox Harrison Stadium Round: 1
| NCAAF | 2021/10/02 20:00 | Seton Hill Griffins v Edinboro | W | 7-17 |
| NCAAF | 2019/10/26 16:00 | Seton Hill Griffins v Edinboro | W | 10-37 |
| NCAAF | 2018/10/20 16:00 | Edinboro v Seton Hill Griffins | W | 56-12 |
| NCAAF | 2022/10/22 16:00 | Clarion Golden Eagles v Edinboro | W | 17-47 |
| NCAAF | 2022/10/15 16:00 | Edinboro v Iup Crimson Hawks | L | 0-41 |
| NCAAF | 2022/10/08 18:00 | Edinboro v Gannon University Golden Knights | L | 17-35 |
| NCAAF | 2022/10/01 18:00 | Mercyhurst v Edinboro | W | 13-16 |
| NCAAF | 2022/09/24 16:00 | California Vulcans v Edinboro | L | 49-7 |
| NCAAF | 2022/09/17 16:00 | Edinboro v Bloomsburg Huskies | W | 23-20 |
| NCAAF | 2022/09/10 16:00 | Shepherd Rams v Edinboro | L | 41-7 |
| NCAAF | 2022/09/03 17:00 | Franklin Pierce Ravens v Edinboro | W | 7-10 |
| NCAAF | 2022/10/22 18:00 | Iup Crimson Hawks v Seton Hill Griffins | L | 44-7 |
| NCAAF | 2022/10/15 22:00 | Seton Hill Griffins v California Vulcans | L | 14-21 |
| NCAAF | 2022/10/08 20:00 | Seton Hill Griffins v Clarion Golden Eagles | L | 13-40 |
| NCAAF | 2022/10/01 16:00 | Gannon University Golden Knights v Seton Hill Griffins | L | 21-10 |
| NCAAF | 2022/09/24 22:00 | Slippery Rock v Seton Hill Griffins | L | 30-2 |
| NCAAF | 2022/09/17 16:00 | Seton Hill Griffins v East Stroudsburg Warriors | L | 7-22 |
| NCAAF | 2022/09/10 17:00 | Shippensburg Raiders v Seton Hill Griffins | L | 36-17 |
| NCAAF | 2022/09/01 23:00 | Wheeling v Seton Hill Griffins | L | 25-11 |