Stadium: Stisser Field at the Knosher Bowl Round: 1
| NCAAF | 2021/10/16 18:00 | Grinnell Pioneers v Knox Prairie Fire | W | 28-49 |
| NCAAF | 2018/10/13 18:00 | Grinnell Pioneers v Knox Prairie Fire | W | 7-28 |
| NCAAF | 2022/10/08 18:00 | Beloit Buccaneers v Knox Prairie Fire | W | 25-34 |
| NCAAF | 2022/10/01 18:00 | Knox Prairie Fire v Chicago Maroons | L | 14-50 |
| NCAAF | 2022/09/17 19:00 | Lake Forest Foresters v Knox Prairie Fire | L | 48-14 |
| NCAAF | 2022/09/10 23:00 | Ripon Red Hawks v Knox Prairie Fire | L | 33-6 |
| NCAAF | 2022/09/03 18:00 | Knox Prairie Fire v Westminster Blue Jays | W | 26-0 |
| NCAAF | 2021/11/13 18:00 | Monmouth Scots v Knox Prairie Fire | L | 38-7 |
| NCAAF | 2021/11/06 18:00 | Knox Prairie Fire v Cornell Rams | L | 34-35 |
| NCAAF | 2021/10/30 18:00 | Knox Prairie Fire v Lawrence Vikings | W | 56-28 |
| NCAAF | 2022/10/08 18:00 | Ripon Red Hawks v Grinnell Pioneers | L | 56-6 |
| NCAAF | 2022/10/01 18:00 | Grinnell Pioneers v Beloit Buccaneers | W | 28-20 |
| NCAAF | 2022/09/17 18:00 | Lawrence Vikings v Grinnell Pioneers | W | 7-28 |
| NCAAF | 2022/09/10 18:00 | Grinnell Pioneers v Monmouth Scots | L | 0-48 |
| NCAAF | 2021/11/13 18:00 | Grinnell Pioneers v Cornell Rams | L | 14-34 |
| NCAAF | 2021/11/06 18:00 | Illinois College Blueboys v Grinnell Pioneers | L | 55-24 |
| NCAAF | 2021/10/30 18:00 | Grinnell Pioneers v Chicago Maroons | L | 3-78 |
| NCAAF | 2021/10/23 18:00 | Lake Forest Foresters v Grinnell Pioneers | L | 79-0 |