Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |
| NCAAF | 2019/11/09 21:00 | Missouri Southern Lions v Emporia State | L | 6-29 |
| NCAAF | 2018/11/03 19:00 | Emporia State v Missouri Southern Lions | L | 48-0 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | L | 20-17 |
| NCAAF | 2022/10/08 19:00 | Missouri Southern Lions v Blue Tigers | W | 37-14 |
| NCAAF | 2022/10/01 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 38-9 |
| NCAAF | 2022/09/25 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | W | 40-21 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |
| NCAAF | 2021/11/13 19:00 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 |
| NCAAF | 2022/10/15 18:00 | Nebraska Kearney v Emporia State | W | 21-44 |
| NCAAF | 2022/10/08 18:00 | Emporia State v Central Missouri Mules | W | 44-27 |
| NCAAF | 2022/10/01 21:00 | Washburn Ichabods Football v Emporia State | W | 35-42 |
| NCAAF | 2022/09/24 18:00 | Emporia State v Pittsburgh State Gorillas | L | 13-14 |
| NCAAF | 2022/09/17 18:00 | Emporia State v Missouri Western Griffons | W | 36-12 |
| NCAAF | 2022/09/09 00:00 | Central Oklahoma v Emporia State | L | 21-13 |
| NCAAF | 2022/09/02 00:00 | Emporia State v Northeastern State Riverhawks | W | 42-17 |
| NCAAF | 2021/11/13 19:30 | NW Missouri State v Emporia State | L | 35-7 |