Stadium: Knight Stadium Round: 1
| NCAAF | 2022/10/22 17:00 | Belhaven Blazers v Southern Virginia Knights | L | 42-6 |
| NCAAF | 2022/10/15 17:00 | Southern Virginia Knights v Maryville Scots | L | 7-45 |
| NCAAF | 2022/10/08 16:00 | Greensboro Pride v Southern Virginia Knights | L | 38-28 |
| NCAAF | 2022/09/24 17:00 | Southern Virginia Knights v Nc Wesleyan Battling Bishops | L | 13-14 |
| NCAAF | 2022/09/17 17:00 | Randolph Macon Yellow Jackets v Southern Virginia Knights | L | 47-20 |
| NCAAF | 2022/09/10 18:00 | Bridgewater Eagles v Southern Virginia Knights | L | 58-10 |
| NCAAF | 2022/09/01 23:00 | Southern Virginia Knights v Wilmington Quakers | L | 27-52 |
| NCAAF | 2021/11/06 16:00 | Nc Wesleyan Battling Bishops v Southern Virginia Knights | L | 19-10 |
| NCAAF | 2022/10/22 17:00 | Methodist Monarchs v Huntingdon Hawks | L | 35-38 |
| NCAAF | 2022/10/15 22:00 | Nc Wesleyan Battling Bishops v Methodist Monarchs | W | 33-34 |
| NCAAF | 2022/10/08 18:00 | Brevard Tornados v Methodist Monarchs | L | 22-20 |
| NCAAF | 2022/10/01 17:00 | Methodist Monarchs v Belhaven Blazers | L | 27-34 |
| NCAAF | 2022/09/24 17:00 | Lagrange Panthers v Methodist Monarchs | W | 28-38 |
| NCAAF | 2022/09/17 17:00 | Methodist Monarchs v Washington And Lee Generals | L | 14-37 |
| NCAAF | 2022/09/10 23:00 | Guilford Quakers v Methodist Monarchs | W | 16-49 |
| NCAAF | 2022/09/03 17:00 | Methodist Monarchs v Shenandoah Hornets | L | 10-27 |