Stadium: Schmidt Stadium Round: 1
| NCAAF | 2021/09/18 17:00 | Misericordia Cougars v Wilkes Colonels | W | 15-35 |
| NCAAF | 2019/10/26 17:00 | Misericordia Cougars v Wilkes Colonels | W | 35-36 |
| NCAAF | 2018/09/22 17:00 | Wilkes Colonels v Misericordia Cougars | L | 45-47 |
| NCAAF | 2022/10/08 16:00 | Alvernia Golden Wolves v Wilkes Colonels | W | 14-35 |
| NCAAF | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | W | 27-0 |
| NCAAF | 2022/09/24 17:00 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 |
| NCAAF | 2022/09/17 16:00 | Wilkes Colonels v Widener Pride | W | 44-20 |
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | W | 21-48 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 |
| NCAAF | 2021/10/30 17:00 | Lycoming Warriors v Wilkes Colonels | L | 30-27 |
| NCAAF | 2022/10/08 17:00 | Misericordia Cougars v Lebanon Valley Flying Dutchmen | L | 12-47 |
| NCAAF | 2022/10/01 17:00 | Misericordia Cougars v Fdu Florham Devils | L | 14-28 |
| NCAAF | 2022/09/24 17:00 | Delaware Valley Aggies v Misericordia Cougars | L | 41-0 |
| NCAAF | 2022/09/17 16:00 | Albright Lions v Misericordia Cougars | W | 21-27 |
| NCAAF | 2022/09/10 17:00 | Misericordia Cougars v Keystone Giants | W | 38-20 |
| NCAAF | 2022/09/03 17:00 | Alfred State Pioneers v Misericordia Cougars | L | 17-14 |
| NCAAF | 2021/11/06 17:00 | Lebanon Valley Flying Dutchmen v Misericordia Cougars | L | 31-17 |
| NCAAF | 2021/10/30 17:00 | Misericordia Cougars v Kings Monarchs | W | 24-17 |