Stadium: Keystone Giants Stadium Round: 1
| NCAAF | 2022/10/15 16:00 | Anna Maria Amcats v Keystone Giants | W | 39-41 |
| NCAAF | 2022/10/08 17:00 | Alfred State Pioneers v Keystone Giants | L | 42-33 |
| NCAAF | 2022/10/01 16:00 | Keystone Giants v Gallaudet Bison | L | 44-52 |
| NCAAF | 2022/09/24 17:30 | Keystone Giants v Hobart Statesmen | L | 6-65 |
| NCAAF | 2022/09/17 17:00 | William Paterson Pioneers v Keystone Giants | L | 27-20 |
| NCAAF | 2022/09/10 17:00 | Misericordia Cougars v Keystone Giants | L | 38-20 |
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | L | 21-48 |
| NCAAF | 2021/11/06 17:00 | Suny Maritime Privateers v Keystone Giants | L | 24-21 |
| NCAAF | 2022/10/15 16:00 | Castleton Spartans v Suny Maritime Privateers | W | 36-33 |
| NCAAF | 2022/10/08 16:00 | Gallaudet Bison v Castleton Spartans | L | 20-17 |
| NCAAF | 2022/10/01 21:00 | Castleton Spartans v Dean Bulldogs | W | 39-0 |
| NCAAF | 2022/09/24 16:00 | Castleton Spartans v St Lawrence Saints | L | 6-34 |
| NCAAF | 2022/09/17 18:00 | Norwich Cadets v Castleton Spartans | L | 26-21 |
| NCAAF | 2022/09/10 18:00 | Castleton Spartans v Fitchburg State Falcons | W | 48-0 |
| NCAAF | 2022/09/03 16:00 | Plymouth State Panthers v Castleton Spartans | L | 20-7 |
| NCAAF | 2021/11/13 17:00 | Castleton Spartans v Gallaudet Bison | W | 31-30 |