Stadium: James Work Memorial Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-30 |
| NCAAF | 2019/10/19 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-42 |
| NCAAF | 2018/09/15 17:00 | Delaware Valley Aggies v Wilkes Colonels | W | 21-10 |
| NCAAF | 2022/10/15 17:00 | Lebanon Valley Flying Dutchmen v Delaware Valley Aggies | W | 10-34 |
| NCAAF | 2022/10/08 16:00 | Delaware Valley Aggies v Lycoming Warriors | W | 21-0 |
| NCAAF | 2022/10/01 16:00 | Stevenson Mustangs v Delaware Valley Aggies | W | 7-26 |
| NCAAF | 2022/09/24 17:00 | Delaware Valley Aggies v Misericordia Cougars | W | 41-0 |
| NCAAF | 2022/09/17 17:00 | Kings Monarchs v Delaware Valley Aggies | W | 6-26 |
| NCAAF | 2022/09/10 16:00 | Montclair State Red Hawks v Delaware Valley Aggies | W | 6-14 |
| NCAAF | 2022/09/03 16:00 | Delaware Valley Aggies v Westminster Titans | W | 22-8 |
| NCAAF | 2021/11/27 17:00 | Delaware Valley Aggies v Muhlenberg Mules | L | 0-14 |
| NCAAF | 2022/10/15 16:00 | Wilkes Colonels v Misericordia Cougars | W | 28-0 |
| NCAAF | 2022/10/08 16:00 | Alvernia Golden Wolves v Wilkes Colonels | W | 14-35 |
| NCAAF | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | W | 27-0 |
| NCAAF | 2022/09/24 17:00 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 |
| NCAAF | 2022/09/17 16:00 | Wilkes Colonels v Widener Pride | W | 44-20 |
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | W | 21-48 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 |