Stadium: Schmidt Stadium Round: 1
| NCAAF | 2021/10/30 17:00 | Lycoming Warriors v Wilkes Colonels | L | 30-27 |
| NCAAF | 2019/09/21 17:00 | Lycoming Warriors v Wilkes Colonels | W | 17-24 |
| NCAAF | 2018/10/27 17:00 | Wilkes Colonels v Lycoming Warriors | W | 14-7 |
| NCAAF | 2022/10/22 17:00 | Delaware Valley Aggies v Wilkes Colonels | L | 27-14 |
| NCAAF | 2022/10/15 16:00 | Wilkes Colonels v Misericordia Cougars | W | 28-0 |
| NCAAF | 2022/10/08 16:00 | Alvernia Golden Wolves v Wilkes Colonels | W | 14-35 |
| NCAAF | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | W | 27-0 |
| NCAAF | 2022/09/24 17:00 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 |
| NCAAF | 2022/09/17 16:00 | Wilkes Colonels v Widener Pride | W | 44-20 |
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | W | 21-48 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2022/10/22 17:00 | Lycoming Warriors v Alvernia Golden Wolves | W | 42-10 |
| NCAAF | 2022/10/15 16:00 | Lycoming Warriors v Stevenson Mustangs | L | 10-24 |
| NCAAF | 2022/10/08 16:00 | Delaware Valley Aggies v Lycoming Warriors | L | 21-0 |
| NCAAF | 2022/10/01 17:00 | Lycoming Warriors v Kings Monarchs | L | 23-28 |
| NCAAF | 2022/09/24 16:00 | Albright Lions v Lycoming Warriors | W | 0-45 |
| NCAAF | 2022/09/10 17:00 | Lebanon Valley Flying Dutchmen v Lycoming Warriors | W | 20-21 |
| NCAAF | 2022/09/03 17:00 | Lycoming Warriors v Susquehanna Crusaders | L | 16-45 |
| NCAAF | 2021/11/13 18:00 | Alvernia Golden Wolves v Lycoming Warriors | W | 0-48 |