Stadium: Pioneer Field Round: 1
| NCAAF | 2022/10/22 17:30 | Tusculum Pioneers v Emory And Henry Wasps | W | 35-9 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | W | 9-10 |
| NCAAF | 2022/10/08 17:30 | Tusculum Pioneers v Carson–Newman Eagles | W | 34-6 |
| NCAAF | 2022/09/29 21:00 | Barton Bulldogs v Tusculum Pioneers | W | 13-14 |
| NCAAF | 2022/09/24 20:00 | Catawba College v Tusculum Pioneers | W | 17-50 |
| NCAAF | 2022/09/17 22:00 | Tusculum Pioneers v Wingate Bulldogs | L | 10-27 |
| NCAAF | 2022/09/10 17:00 | Chowan Hawks v Tusculum Pioneers | W | 21-23 |
| NCAAF | 2022/09/01 22:00 | Tusculum Pioneers v St Augustines Falcons | W | 70-13 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | L | 13-28 |
| NCAAF | 2022/10/15 22:00 | Carson–Newman Eagles v Erskine Flying Fleet | L | 37-0 |
| NCAAF | 2022/10/08 20:00 | Erskine Flying Fleet v Mars Hill Lions | L | 13-33 |
| NCAAF | 2022/10/01 18:00 | Erskine Flying Fleet v Wingate Bulldogs | L | 7-31 |
| NCAAF | 2022/09/24 22:00 | Newberry Wolves v Erskine Flying Fleet | L | 32-14 |
| NCAAF | 2022/09/17 20:00 | Erskine Flying Fleet v Lenoir Rhyne Bears | L | 20-42 |
| NCAAF | 2022/09/10 20:00 | Clark Atlanta University v Erskine Flying Fleet | W | 19-23 |
| NCAAF | 2021/11/13 18:00 | Erskine Flying Fleet v Kentucky Thorobreds | L | 17-41 |