Stadium: Meares Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Mars Hill Lions v Tusculum Pioneers | W | 20-7 |
| NCAAF | 2019/11/09 18:30 | Tusculum Pioneers v Mars Hill Lions | L | 24-7 |
| NCAAF | 2018/10/06 17:30 | Mars Hill Lions v Tusculum Pioneers | L | 28-31 |
| NCAAF | 2022/10/29 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | W | 16-20 |
| NCAAF | 2022/10/22 17:00 | Mars Hill Lions v Carson–Newman Eagles | W | 44-13 |
| NCAAF | 2022/10/15 17:30 | Mars Hill Lions v Emory And Henry Wasps | W | 49-14 |
| NCAAF | 2022/10/08 20:00 | Erskine Flying Fleet v Mars Hill Lions | W | 13-33 |
| NCAAF | 2022/09/29 23:00 | Mars Hill Lions v Limestone Saints | L | 14-17 |
| NCAAF | 2022/09/24 18:00 | Barton Bulldogs v Mars Hill Lions | W | 18-24 |
| NCAAF | 2022/09/17 17:00 | Mars Hill Lions v Catawba College | W | 38-7 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | L | 44-7 |
| NCAAF | 2022/10/29 17:30 | Tusculum Pioneers v Erskine Flying Fleet | W | 49-14 |
| NCAAF | 2022/10/22 17:30 | Tusculum Pioneers v Emory And Henry Wasps | W | 35-9 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | W | 9-10 |
| NCAAF | 2022/10/08 17:30 | Tusculum Pioneers v Carson–Newman Eagles | W | 34-6 |
| NCAAF | 2022/09/29 21:00 | Barton Bulldogs v Tusculum Pioneers | W | 13-14 |
| NCAAF | 2022/09/24 20:00 | Catawba College v Tusculum Pioneers | W | 17-50 |
| NCAAF | 2022/09/17 22:00 | Tusculum Pioneers v Wingate Bulldogs | L | 10-27 |
| NCAAF | 2022/09/10 17:00 | Chowan Hawks v Tusculum Pioneers | W | 21-23 |