Stadium: Lewis C. Everett Stadium Round: 1
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 27-28 |
| NCAAF | 2019/10/26 17:00 | Guilford Quakers v Hampden Sydney Tigers | L | 37-27 |
| NCAAF | 2018/10/20 17:00 | Hampden Sydney Tigers v Guilford Quakers | W | 38-35 |
| NCAAF | 2022/10/22 17:00 | Washington And Lee Generals v Hampden Sydney Tigers | W | 43-44 |
| NCAAF | 2022/10/15 17:00 | Hampden Sydney Tigers v Averett Cougars | W | 37-26 |
| NCAAF | 2022/10/08 19:30 | Ferrum Panthers v Hampden Sydney Tigers | W | 16-35 |
| NCAAF | 2022/10/01 18:00 | Bridgewater Eagles v Hampden Sydney Tigers | L | 27-17 |
| NCAAF | 2022/09/17 17:00 | Hampden Sydney Tigers v Greensboro Pride | W | 70-28 |
| NCAAF | 2022/09/10 17:00 | Hampden Sydney Tigers v Widener Pride | L | 27-31 |
| NCAAF | 2022/09/03 17:00 | Wabash Little Giants v Hampden Sydney Tigers | L | 52-48 |
| NCAAF | 2021/11/13 18:00 | Randolph Macon Yellow Jackets v Hampden Sydney Tigers | L | 37-14 |
| NCAAF | 2022/10/22 17:00 | Guilford Quakers v Ferrum Panthers | L | 17-31 |
| NCAAF | 2022/10/15 17:00 | Shenandoah Hornets v Guilford Quakers | L | 38-35 |
| NCAAF | 2022/10/08 18:00 | Guilford Quakers v Washington And Lee Generals | L | 6-31 |
| NCAAF | 2022/10/01 17:00 | Randolph Macon Yellow Jackets v Guilford Quakers | L | 48-19 |
| NCAAF | 2022/09/17 17:00 | Guilford Quakers v Huntingdon Hawks | L | 7-47 |
| NCAAF | 2022/09/10 23:00 | Guilford Quakers v Methodist Monarchs | L | 16-49 |
| NCAAF | 2022/09/03 16:00 | Greensboro Pride v Guilford Quakers | W | 37-48 |
| NCAAF | 2021/11/13 19:00 | Bridgewater Eagles v Guilford Quakers | L | 43-0 |