Stadium: Callaway Stadium Round: 1
| NCAAF | 2022/10/29 00:00 | Belhaven Blazers v Lagrange Panthers | L | 70-16 |
| NCAAF | 2022/10/22 19:00 | Brevard Tornados v Lagrange Panthers | L | 24-10 |
| NCAAF | 2022/10/08 17:00 | Lagrange Panthers v Maryville Scots | L | 17-56 |
| NCAAF | 2022/09/30 17:00 | Nc Wesleyan Battling Bishops v Lagrange Panthers | L | 37-22 |
| NCAAF | 2022/09/24 17:00 | Lagrange Panthers v Methodist Monarchs | L | 28-38 |
| NCAAF | 2022/09/17 17:00 | Lagrange Panthers v Ferrum Panthers | W | 44-38 |
| NCAAF | 2022/09/10 22:00 | Berry Vikings v Lagrange Panthers | L | 56-10 |
| NCAAF | 2021/11/13 18:00 | Lagrange Panthers v Huntingdon Hawks | L | 9-55 |
| NCAAF | 2022/10/29 17:00 | Southern Virginia Knights v Methodist Monarchs | L | 23-36 |
| NCAAF | 2022/10/22 17:00 | Belhaven Blazers v Southern Virginia Knights | L | 42-6 |
| NCAAF | 2022/10/15 17:00 | Southern Virginia Knights v Maryville Scots | L | 7-45 |
| NCAAF | 2022/10/08 16:00 | Greensboro Pride v Southern Virginia Knights | L | 38-28 |
| NCAAF | 2022/09/24 17:00 | Southern Virginia Knights v Nc Wesleyan Battling Bishops | L | 13-14 |
| NCAAF | 2022/09/17 17:00 | Randolph Macon Yellow Jackets v Southern Virginia Knights | L | 47-20 |
| NCAAF | 2022/09/10 18:00 | Bridgewater Eagles v Southern Virginia Knights | L | 58-10 |
| NCAAF | 2022/09/01 23:00 | Southern Virginia Knights v Wilmington Quakers | L | 27-52 |