Stadium: Mount Sports Complex/Schueler Field & Track Round: 1
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2019/10/05 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | W | 59-6 |
| NCAAF | 2018/10/20 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 0-20 |
| NCAAF | 2022/10/01 17:30 | Manchester Spartans v Mount St. Joseph Lions | W | 20-55 |
| NCAAF | 2022/09/17 17:30 | Mount St. Joseph Lions v Hope Flying Dutchmen | W | 33-28 |
| NCAAF | 2022/09/10 16:00 | Alfred Saxons v Mount St. Joseph Lions | W | 37-43 |
| NCAAF | 2022/09/03 17:30 | Mount St. Joseph Lions v Baldwin Wallace Yellow Jackets | W | 31-28 |
| NCAAF | 2021/11/13 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | L | 58-21 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | W | 23-6 |
| NCAAF | 2021/10/30 17:30 | Mount St. Joseph Lions v Anderson Ravens | W | 35-18 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | L | 20-37 |
| NCAAF | 2022/09/24 16:00 | Alfred State Pioneers v Defiance Yellow Jackets | L | 42-33 |
| NCAAF | 2022/09/17 17:30 | Defiance Yellow Jackets v Kalamazoo Hornets | L | 23-42 |
| NCAAF | 2022/09/03 17:30 | Mount Union v Defiance Yellow Jackets | L | 65-0 |
| NCAAF | 2021/11/13 18:30 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 |
| NCAAF | 2021/11/06 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 |
| NCAAF | 2021/10/30 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |