Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | W | 32-52 |
| NCAAF | 2019/09/12 23:00 | Blue Tigers v Missouri Southern Lions | W | 14-38 |
| NCAAF | 2022/10/01 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 38-9 |
| NCAAF | 2022/09/25 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | W | 40-21 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |
| NCAAF | 2021/11/13 19:00 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | L | 7-49 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2022/10/01 19:00 | Blue Tigers v Central Oklahoma | L | 3-45 |
| NCAAF | 2022/09/24 19:00 | Northeastern State Riverhawks v Blue Tigers | L | 38-10 |
| NCAAF | 2022/09/17 23:00 | Blue Tigers v Fort Hays State University Tigers | L | 14-51 |
| NCAAF | 2022/09/10 19:00 | Blue Tigers v NW Missouri State | L | 20-58 |
| NCAAF | 2022/09/01 23:00 | Washburn Ichabods Football v Blue Tigers | L | 45-3 |
| NCAAF | 2021/11/13 17:00 | Blue Tigers v Missouri Western Griffons | L | 12-41 |
| NCAAF | 2021/11/06 18:00 | Emporia State v Blue Tigers | L | 56-21 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | L | 35-77 |