Stadium: Gaffney High School Reservation Stadium Round: 1
| NCAAF | 2022/11/05 16:00 | Limestone Saints v Barton Bulldogs | W | 34-28 |
| NCAAF | 2022/10/29 20:00 | Newberry Wolves v Limestone Saints | W | 37-42 |
| NCAAF | 2022/10/22 22:00 | Catawba College v Limestone Saints | W | 23-48 |
| NCAAF | 2022/10/15 16:00 | Limestone Saints v Wingate Bulldogs | L | 21-28 |
| NCAAF | 2022/10/08 17:00 | Lenoir Rhyne Bears v Limestone Saints | L | 51-30 |
| NCAAF | 2022/09/29 23:00 | Mars Hill Lions v Limestone Saints | W | 14-17 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 27-13 |
| NCAAF | 2022/09/17 17:00 | Carson–Newman Eagles v Limestone Saints | W | 37-40 |
| NCAAF | 2022/11/05 20:00 | Erskine Flying Fleet v Emory And Henry Wasps | W | 0-32 |
| NCAAF | 2022/10/29 17:00 | Emory And Henry Wasps v Carson–Newman Eagles | L | 7-21 |
| NCAAF | 2022/10/22 17:30 | Tusculum Pioneers v Emory And Henry Wasps | L | 35-9 |
| NCAAF | 2022/10/15 17:30 | Mars Hill Lions v Emory And Henry Wasps | L | 49-14 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | W | 34-14 |
| NCAAF | 2022/09/30 19:00 | Emory And Henry Wasps v Catawba College | W | 38-23 |
| NCAAF | 2022/09/24 22:00 | Wingate Bulldogs v Emory And Henry Wasps | W | 10-17 |
| NCAAF | 2022/09/17 17:00 | Emory And Henry Wasps v Newberry Wolves | L | 23-26 |