Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | L | 49-10 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | L | 6-62 |
| NCAAF | 2022/10/01 20:00 | Tiffin Dragons v Lake Erie | L | 52-27 |
| NCAAF | 2022/09/24 18:00 | Southwest Baptist University Bearcats v Lake Erie | L | 52-31 |
| NCAAF | 2022/09/17 22:00 | Lake Erie v McKendree | L | 37-38 |
| NCAAF | 2022/09/11 00:00 | Kentucky Wesleyan v Lake Erie | W | 21-26 |
| NCAAF | 2022/09/03 19:00 | Lake Erie v Hillsdale Chargers | L | 31-35 |
| NCAAF | 2021/11/13 18:00 | Lake Erie v Walsh U. Cavaliers | L | 7-24 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2022/10/01 17:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 21-0 |
| NCAAF | 2022/09/24 17:00 | Ohio Dominican Panthers v Indianapolis Greyhounds | L | 38-44 |
| NCAAF | 2022/09/17 17:00 | Ohio Dominican Panthers v William Jewell College Cardinals | W | 31-21 |
| NCAAF | 2022/09/10 17:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 28-13 |
| NCAAF | 2022/09/03 16:00 | Ohio Dominican Panthers v Findlay Oilers | W | 28-14 |
| NCAAF | 2021/11/13 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | L | 21-17 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 34-21 |