Stadium: Fred Selfe Stadium Round: 1
| NCAAF | 2022/09/30 19:00 | Emory And Henry Wasps v Catawba College | W | 38-23 |
| NCAAF | 2022/09/24 22:00 | Wingate Bulldogs v Emory And Henry Wasps | W | 10-17 |
| NCAAF | 2022/09/17 17:00 | Emory And Henry Wasps v Newberry Wolves | L | 23-26 |
| NCAAF | 2022/09/10 22:00 | Bluefield College Rams v Emory And Henry Wasps | W | 33-41 |
| NCAAF | 2022/09/03 17:00 | Emory And Henry Wasps v Concord University Mountain Lions | L | 20-27 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | W | 41-23 |
| NCAAF | 2021/11/06 17:00 | Guilford Quakers v Emory And Henry Wasps | W | 13-66 |
| NCAAF | 2021/10/30 17:00 | Emory And Henry Wasps v Washington And Lee Generals | L | 28-30 |
| NCAAF | 2022/09/30 19:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 10-42 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2022/09/17 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 20-40 |
| NCAAF | 2022/09/10 23:00 | North Alabama v Virginia Wise Highland Cavaliers | L | 49-17 |
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | W | 41-9 |
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 24-36 |
| NCAAF | 2021/11/06 17:00 | Catawba College v Virginia Wise Highland Cavaliers | W | 7-30 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |