Round: 1
| NCAAF | 2022/10/15 22:00 | Carson–Newman Eagles v Erskine Flying Fleet | L | 37-0 |
| NCAAF | 2022/10/08 20:00 | Erskine Flying Fleet v Mars Hill Lions | L | 13-33 |
| NCAAF | 2022/10/01 18:00 | Erskine Flying Fleet v Wingate Bulldogs | L | 7-31 |
| NCAAF | 2022/09/24 22:00 | Newberry Wolves v Erskine Flying Fleet | L | 32-14 |
| NCAAF | 2022/09/17 20:00 | Erskine Flying Fleet v Lenoir Rhyne Bears | L | 20-42 |
| NCAAF | 2022/09/10 20:00 | Clark Atlanta University v Erskine Flying Fleet | W | 19-23 |
| NCAAF | 2021/11/13 18:00 | Erskine Flying Fleet v Kentucky Thorobreds | L | 17-41 |
| NCAAF | 2021/11/06 17:00 | Shorter v Erskine Flying Fleet | L | 38-7 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 9-10 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | L | 34-14 |
| NCAAF | 2022/09/30 19:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 10-42 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2022/09/17 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 20-40 |
| NCAAF | 2022/09/10 23:00 | North Alabama v Virginia Wise Highland Cavaliers | L | 49-17 |
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | W | 41-9 |
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 24-36 |