Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2019/09/21 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 14-21 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | W | 13-28 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 9-10 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | L | 34-14 |
| NCAAF | 2022/09/30 19:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 10-42 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2022/09/17 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 20-40 |
| NCAAF | 2022/09/10 23:00 | North Alabama v Virginia Wise Highland Cavaliers | L | 49-17 |
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | W | 41-9 |
| NCAAF | 2022/10/22 17:00 | Mars Hill Lions v Carson–Newman Eagles | W | 44-13 |
| NCAAF | 2022/10/15 17:30 | Mars Hill Lions v Emory And Henry Wasps | W | 49-14 |
| NCAAF | 2022/10/08 20:00 | Erskine Flying Fleet v Mars Hill Lions | W | 13-33 |
| NCAAF | 2022/09/29 23:00 | Mars Hill Lions v Limestone Saints | L | 14-17 |
| NCAAF | 2022/09/24 18:00 | Barton Bulldogs v Mars Hill Lions | W | 18-24 |
| NCAAF | 2022/09/17 17:00 | Mars Hill Lions v Catawba College | W | 38-7 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | L | 44-7 |
| NCAAF | 2021/11/13 20:00 | Wingate Bulldogs v Mars Hill Lions | L | 26-19 |