Stadium: Burke-Tarr Stadium Round: 1
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | L | 33-7 |
| NCAAF | 2019/09/28 17:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | W | 42-7 |
| NCAAF | 2022/10/29 17:00 | Emory And Henry Wasps v Carson–Newman Eagles | W | 7-21 |
| NCAAF | 2022/10/22 17:00 | Mars Hill Lions v Carson–Newman Eagles | L | 44-13 |
| NCAAF | 2022/10/15 22:00 | Carson–Newman Eagles v Erskine Flying Fleet | W | 37-0 |
| NCAAF | 2022/10/08 17:30 | Tusculum Pioneers v Carson–Newman Eagles | L | 34-6 |
| NCAAF | 2022/10/01 17:00 | Carson–Newman Eagles v Newberry Wolves | W | 24-14 |
| NCAAF | 2022/09/24 22:00 | Lenoir Rhyne Bears v Carson–Newman Eagles | L | 34-13 |
| NCAAF | 2022/09/17 17:00 | Carson–Newman Eagles v Limestone Saints | L | 37-40 |
| NCAAF | 2022/09/10 17:00 | Carson–Newman Eagles v Franklin Pierce Ravens | W | 27-6 |
| NCAAF | 2022/10/29 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 16-20 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | W | 13-28 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 9-10 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | L | 34-14 |
| NCAAF | 2022/09/30 19:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 10-42 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2022/09/17 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 20-40 |
| NCAAF | 2022/09/10 23:00 | North Alabama v Virginia Wise Highland Cavaliers | L | 49-17 |