Stadium: Spratt Memorial Stadium Round: 1
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | W | 28-45 |
| NCAAF | 2019/10/12 21:00 | Missouri Western Griffons v Missouri Southern Lions | W | 43-34 |
| NCAAF | 2018/10/06 19:00 | Missouri Southern Lions v Missouri Western Griffons | W | 10-33 |
| NCAAF | 2022/10/22 19:00 | Pittsburgh State Gorillas v Missouri Western Griffons | L | 28-16 |
| NCAAF | 2022/10/15 21:00 | Northeastern State Riverhawks v Missouri Western Griffons | W | 16-23 |
| NCAAF | 2022/10/08 21:00 | Missouri Western Griffons v Nebraska Kearney | L | 18-39 |
| NCAAF | 2022/10/01 18:30 | NW Missouri State v Missouri Western Griffons | L | 16-3 |
| NCAAF | 2022/09/24 23:00 | Missouri Western Griffons v Washburn Ichabods Football | L | 31-38 |
| NCAAF | 2022/09/17 18:00 | Emporia State v Missouri Western Griffons | L | 36-12 |
| NCAAF | 2022/09/09 00:00 | Fort Hays State University Tigers v Missouri Western Griffons | W | 19-35 |
| NCAAF | 2022/09/02 00:00 | Missouri Western Griffons v Central Oklahoma | W | 35-0 |
| NCAAF | 2022/10/22 19:00 | Missouri Southern Lions v Emporia State | L | 21-24 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | L | 20-17 |
| NCAAF | 2022/10/08 19:00 | Missouri Southern Lions v Blue Tigers | W | 37-14 |
| NCAAF | 2022/10/01 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 38-9 |
| NCAAF | 2022/09/25 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | W | 40-21 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |