Stadium: Wilkins Stadium Round: 1
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |
| NCAAF | 2019/10/26 19:00 | East Central Tigers v Southern Arkansas Muleriders | W | 23-24 |
| NCAAF | 2018/10/20 19:30 | Southern Arkansas Muleriders v East Central Tigers | W | 48-9 |
| NCAAF | 2022/09/24 23:00 | Southern Arkansas Muleriders v Henderson State Reddies | W | 28-24 |
| NCAAF | 2022/09/17 23:00 | Harding Bisons v Southern Arkansas Muleriders | L | 37-17 |
| NCAAF | 2022/09/10 23:00 | Southwestern Oklahoma State Bulldogs v Southern Arkansas Muleriders | L | 24-20 |
| NCAAF | 2022/09/01 23:00 | Southern Arkansas Muleriders v Northwestern Oklahoma State Rangers | W | 62-31 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2022/09/24 23:00 | East Central Tigers v Northwestern Oklahoma State Rangers | W | 31-3 |
| NCAAF | 2022/09/17 19:00 | Southern Nazarene v East Central Tigers | W | 21-44 |
| NCAAF | 2022/09/10 23:00 | Arkansas Tech Wonder Boys v East Central Tigers | L | 35-13 |
| NCAAF | 2022/09/01 23:00 | East Central Tigers v Harding Bisons | L | 12-29 |
| NCAAF | 2021/11/13 20:00 | Southeastern Oklahoma State Savage Storm v East Central Tigers | W | 28-30 |
| NCAAF | 2021/11/06 19:00 | Arkansas Monticello Boll Weevils v East Central Tigers | W | 10-35 |
| NCAAF | 2021/10/30 19:00 | East Central Tigers v Ouachita Baptist Tigers | L | 28-43 |
| NCAAF | 2021/10/23 19:00 | Southwestern Oklahoma State Bulldogs v East Central Tigers | W | 34-44 |