Stadium: Fred Selfe Stadium Round: 1
| NCAAF | 2022/10/22 17:30 | Tusculum Pioneers v Emory And Henry Wasps | L | 35-9 |
| NCAAF | 2022/10/15 17:30 | Mars Hill Lions v Emory And Henry Wasps | L | 49-14 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | W | 34-14 |
| NCAAF | 2022/09/30 19:00 | Emory And Henry Wasps v Catawba College | W | 38-23 |
| NCAAF | 2022/09/24 22:00 | Wingate Bulldogs v Emory And Henry Wasps | W | 10-17 |
| NCAAF | 2022/09/17 17:00 | Emory And Henry Wasps v Newberry Wolves | L | 23-26 |
| NCAAF | 2022/09/10 22:00 | Bluefield College Rams v Emory And Henry Wasps | W | 33-41 |
| NCAAF | 2022/09/03 17:00 | Emory And Henry Wasps v Concord University Mountain Lions | L | 20-27 |
| NCAAF | 2022/10/22 17:00 | Mars Hill Lions v Carson–Newman Eagles | L | 44-13 |
| NCAAF | 2022/10/15 22:00 | Carson–Newman Eagles v Erskine Flying Fleet | W | 37-0 |
| NCAAF | 2022/10/08 17:30 | Tusculum Pioneers v Carson–Newman Eagles | L | 34-6 |
| NCAAF | 2022/10/01 17:00 | Carson–Newman Eagles v Newberry Wolves | W | 24-14 |
| NCAAF | 2022/09/24 22:00 | Lenoir Rhyne Bears v Carson–Newman Eagles | L | 34-13 |
| NCAAF | 2022/09/17 17:00 | Carson–Newman Eagles v Limestone Saints | L | 37-40 |
| NCAAF | 2022/09/10 17:00 | Carson–Newman Eagles v Franklin Pierce Ravens | W | 27-6 |
| NCAAF | 2022/09/01 23:00 | West Georgia v Carson–Newman Eagles | L | 38-7 |