Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2019/11/09 18:30 | Defiance Yellow Jackets v Manchester Spartans | L | 0-19 |
| NCAAF | 2019/09/19 23:00 | Manchester Spartans v Defiance Yellow Jackets | L | 52-21 |
| NCAAF | 2018/09/15 22:00 | Manchester Spartans v Defiance Yellow Jackets | L | 57-26 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 76-35 |
| NCAAF | 2022/10/22 17:30 | Defiance Yellow Jackets v Anderson Ravens | W | 32-22 |
| NCAAF | 2022/10/15 17:30 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 48-19 |
| NCAAF | 2022/10/08 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 55-35 |
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | L | 20-37 |
| NCAAF | 2022/09/24 16:00 | Alfred State Pioneers v Defiance Yellow Jackets | L | 42-33 |
| NCAAF | 2022/09/17 17:30 | Defiance Yellow Jackets v Kalamazoo Hornets | L | 23-42 |
| NCAAF | 2022/09/03 17:30 | Mount Union v Defiance Yellow Jackets | L | 65-0 |
| NCAAF | 2022/10/29 17:30 | Manchester Spartans v Franklin College Grizzlies | L | 6-24 |
| NCAAF | 2022/10/22 17:30 | Manchester Spartans v Bluffton Beavers | L | 44-46 |
| NCAAF | 2022/10/15 17:30 | Manchester Spartans v Hanover | L | 20-51 |
| NCAAF | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | L | 48-14 |
| NCAAF | 2022/10/01 17:30 | Manchester Spartans v Mount St. Joseph Lions | L | 20-55 |
| NCAAF | 2022/09/17 18:00 | Greenville Panthers v Manchester Spartans | L | 49-22 |
| NCAAF | 2022/09/10 22:00 | Alma College Scots v Manchester Spartans | L | 49-7 |
| NCAAF | 2022/09/03 23:00 | North Park Vikings v Manchester Spartans | W | 14-23 |