Round: 1
| NCAAF | 2022/10/29 17:30 | Tusculum Pioneers v Erskine Flying Fleet | L | 49-14 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | L | 13-28 |
| NCAAF | 2022/10/15 22:00 | Carson–Newman Eagles v Erskine Flying Fleet | L | 37-0 |
| NCAAF | 2022/10/08 20:00 | Erskine Flying Fleet v Mars Hill Lions | L | 13-33 |
| NCAAF | 2022/10/01 18:00 | Erskine Flying Fleet v Wingate Bulldogs | L | 7-31 |
| NCAAF | 2022/09/24 22:00 | Newberry Wolves v Erskine Flying Fleet | L | 32-14 |
| NCAAF | 2022/09/17 20:00 | Erskine Flying Fleet v Lenoir Rhyne Bears | L | 20-42 |
| NCAAF | 2022/09/10 20:00 | Clark Atlanta University v Erskine Flying Fleet | W | 19-23 |
| NCAAF | 2022/10/29 17:00 | Emory And Henry Wasps v Carson–Newman Eagles | L | 7-21 |
| NCAAF | 2022/10/22 17:30 | Tusculum Pioneers v Emory And Henry Wasps | L | 35-9 |
| NCAAF | 2022/10/15 17:30 | Mars Hill Lions v Emory And Henry Wasps | L | 49-14 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | W | 34-14 |
| NCAAF | 2022/09/30 19:00 | Emory And Henry Wasps v Catawba College | W | 38-23 |
| NCAAF | 2022/09/24 22:00 | Wingate Bulldogs v Emory And Henry Wasps | W | 10-17 |
| NCAAF | 2022/09/17 17:00 | Emory And Henry Wasps v Newberry Wolves | L | 23-26 |
| NCAAF | 2022/09/10 22:00 | Bluefield College Rams v Emory And Henry Wasps | W | 33-41 |