Stadium: First Security Stadium Round: 1
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding Bisons | W | 21-46 |
| NCAAF | 2019/09/28 23:00 | Harding Bisons v Henderson State Reddies | W | 14-13 |
| NCAAF | 2018/08/31 00:00 | Henderson State Reddies v Harding Bisons | W | 17-41 |
| NCAAF | 2022/10/08 19:00 | Southern Nazarene v Harding Bisons | W | 28-56 |
| NCAAF | 2022/10/01 19:00 | Harding Bisons v Oklahoma Baptist Bison | W | 38-23 |
| NCAAF | 2022/09/24 23:00 | Ouachita Baptist Tigers v Harding Bisons | L | 21-13 |
| NCAAF | 2022/09/17 23:00 | Harding Bisons v Southern Arkansas Muleriders | W | 37-17 |
| NCAAF | 2022/09/11 00:00 | Harding Bisons v Southeastern Oklahoma State Savage Storm | W | 38-13 |
| NCAAF | 2022/09/01 23:00 | East Central Tigers v Harding Bisons | W | 12-29 |
| NCAAF | 2021/11/27 19:00 | Harding Bisons v NW Missouri State | L | 9-28 |
| NCAAF | 2021/11/20 19:00 | Harding Bisons v Washburn Ichabods Football | W | 30-14 |
| NCAAF | 2022/10/08 19:00 | East Central Tigers v Henderson State Reddies | L | 31-10 |
| NCAAF | 2022/10/01 19:00 | Henderson State Reddies v Southeastern Oklahoma State Savage Storm | W | 31-23 |
| NCAAF | 2022/09/24 23:00 | Southern Arkansas Muleriders v Henderson State Reddies | L | 28-24 |
| NCAAF | 2022/09/17 23:00 | Henderson State Reddies v Arkansas Monticello Boll Weevils | W | 37-27 |
| NCAAF | 2022/09/10 23:00 | Northwestern Oklahoma State Rangers v Henderson State Reddies | W | 27-51 |
| NCAAF | 2022/09/02 00:00 | Henderson State Reddies v Southwestern Oklahoma State Bulldogs | W | 30-13 |
| NCAAF | 2021/11/13 19:00 | Ouachita Baptist Tigers v Henderson State Reddies | L | 31-28 |
| NCAAF | 2021/11/06 19:00 | Oklahoma Baptist Bison v Henderson State Reddies | W | 34-36 |