Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2022/10/15 16:00 | Walsh U. Cavaliers v Lake Erie | W | 15-22 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | L | 7-38 |
| NCAAF | 2022/10/01 20:00 | Tiffin Dragons v Lake Erie | L | 52-27 |
| NCAAF | 2022/09/24 18:00 | Southwest Baptist University Bearcats v Lake Erie | L | 52-31 |
| NCAAF | 2022/09/17 22:00 | Lake Erie v McKendree | L | 37-38 |
| NCAAF | 2022/09/11 00:00 | Kentucky Wesleyan v Lake Erie | W | 21-26 |
| NCAAF | 2022/09/03 19:00 | Lake Erie v Hillsdale Chargers | L | 31-35 |
| NCAAF | 2021/11/13 18:00 | Lake Erie v Walsh U. Cavaliers | L | 7-24 |
| NCAAF | 2022/10/15 17:00 | Northwood Timberwolves v Hillsdale Chargers | L | 7-41 |
| NCAAF | 2022/10/08 18:00 | Findlay Oilers v Northwood Timberwolves | L | 34-14 |
| NCAAF | 2022/10/01 23:00 | Ashland Eagles v Northwood Timberwolves | L | 56-17 |
| NCAAF | 2022/09/24 18:00 | Davenport Panthers v Northwood Timberwolves | L | 51-17 |
| NCAAF | 2022/09/17 17:00 | Northwood Timberwolves v Saginaw Valley State Cardinals | L | 14-35 |
| NCAAF | 2022/09/10 17:00 | Northwood Timberwolves v Madonna University Crusaders | W | 38-0 |
| NCAAF | 2022/09/03 17:00 | Northwood Timberwolves v Kentucky Wesleyan | W | 55-13 |
| NCAAF | 2021/11/13 18:00 | Northern Michigan Wildcats v Northwood Timberwolves | L | 34-26 |