Stadium: Blackstock Stadium Round: 1
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2019/09/28 17:00 | Depauw Tigers v Wittenberg Tigers | L | 10-17 |
| NCAAF | 2018/10/20 17:00 | Wittenberg Tigers v Depauw Tigers | L | 38-23 |
| NCAAF | 2022/10/01 23:00 | Denison Big Red v Depauw Tigers | W | 13-17 |
| NCAAF | 2022/09/24 17:00 | Depauw Tigers v Wooster Scots | W | 59-0 |
| NCAAF | 2022/09/17 16:00 | Hiram Terriers v Depauw Tigers | W | 0-44 |
| NCAAF | 2022/09/10 22:00 | Anderson Ravens v Depauw Tigers | W | 0-55 |
| NCAAF | 2022/09/03 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 17-14 |
| NCAAF | 2021/11/27 18:00 | UW-Whitewater v Depauw Tigers | L | 45-0 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 26-21 |
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | L | 42-35 |
| NCAAF | 2022/10/01 17:00 | Wittenberg Tigers v Wabash Little Giants | L | 35-42 |
| NCAAF | 2022/09/24 16:00 | Hiram Terriers v Wittenberg Tigers | W | 14-38 |
| NCAAF | 2022/09/17 17:00 | Kenyon Lords v Wittenberg Tigers | W | 28-51 |
| NCAAF | 2022/09/03 16:00 | Cortland Red Dragons v Wittenberg Tigers | L | 48-28 |
| NCAAF | 2021/11/13 18:00 | Wittenberg Tigers v Wooster Scots | W | 44-29 |
| NCAAF | 2021/11/06 17:00 | Wabash Little Giants v Wittenberg Tigers | W | 14-35 |
| NCAAF | 2021/10/30 17:00 | Allegheny Gators v Wittenberg Tigers | W | 19-29 |
| NCAAF | 2021/10/23 22:00 | Wittenberg Tigers v Kenyon Lords | W | 38-14 |