Stadium: Blackstock Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Depauw Tigers v Oberlin Yeomen | W | 66-13 |
| NCAAF | 2019/11/09 18:00 | Depauw Tigers v Oberlin Yeomen | W | 34-0 |
| NCAAF | 2018/10/06 17:00 | Oberlin Yeomen v Depauw Tigers | W | 26-28 |
| NCAAF | 2022/10/29 17:00 | Kenyon Lords v Depauw Tigers | W | 35-58 |
| NCAAF | 2022/10/22 17:00 | Ohio Wesleyan Battling Bishops v Depauw Tigers | W | 21-22 |
| NCAAF | 2022/10/08 17:00 | Depauw Tigers v Wittenberg Tigers | L | 7-30 |
| NCAAF | 2022/10/01 23:00 | Denison Big Red v Depauw Tigers | W | 13-17 |
| NCAAF | 2022/09/24 17:00 | Depauw Tigers v Wooster Scots | W | 59-0 |
| NCAAF | 2022/09/17 16:00 | Hiram Terriers v Depauw Tigers | W | 0-44 |
| NCAAF | 2022/09/10 22:00 | Anderson Ravens v Depauw Tigers | W | 0-55 |
| NCAAF | 2022/09/03 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 17-14 |
| NCAAF | 2022/10/29 23:00 | Ohio Wesleyan Battling Bishops v Oberlin Yeomen | L | 77-0 |
| NCAAF | 2022/10/22 17:00 | Oberlin Yeomen v Wabash Little Giants | L | 20-66 |
| NCAAF | 2022/10/15 20:00 | Wittenberg Tigers v Oberlin Yeomen | L | 62-7 |
| NCAAF | 2022/10/08 17:00 | Oberlin Yeomen v Kenyon Lords | L | 21-28 |
| NCAAF | 2022/10/01 17:00 | Oberlin Yeomen v Hiram Terriers | L | 7-34 |
| NCAAF | 2022/09/17 17:00 | Denison Big Red v Oberlin Yeomen | L | 51-10 |
| NCAAF | 2022/09/10 16:00 | Oberlin Yeomen v Alvernia Golden Wolves | L | 35-38 |
| NCAAF | 2022/09/03 17:00 | Kalamazoo Hornets v Oberlin Yeomen | L | 21-14 |