Stadium: William H. Greene Stadium Round: 1
| NCAAF | 2021/10/02 18:00 | McKendree v William Jewell College Cardinals | L | 52-10 |
| NCAAF | 2019/10/19 18:00 | William Jewell College Cardinals v McKendree | L | 12-42 |
| NCAAF | 2018/10/27 18:00 | McKendree v William Jewell College Cardinals | L | 47-31 |
| NCAAF | 2022/09/24 18:00 | William Jewell College Cardinals v Kentucky Wesleyan | W | 24-17 |
| NCAAF | 2022/09/17 17:00 | Ohio Dominican Panthers v William Jewell College Cardinals | L | 31-21 |
| NCAAF | 2022/09/10 17:00 | Black Hills State v William Jewell College Cardinals | L | 38-19 |
| NCAAF | 2022/09/02 00:00 | William Jewell College Cardinals v Colorado Mesa University Mavericks | L | 14-37 |
| NCAAF | 2021/11/13 19:00 | William Jewell College Cardinals v Quincy | L | 17-51 |
| NCAAF | 2021/11/06 18:00 | Indianapolis Greyhounds v William Jewell College Cardinals | L | 45-14 |
| NCAAF | 2021/10/30 18:00 | William Jewell College Cardinals v Lindenwood | L | 10-53 |
| NCAAF | 2021/10/23 19:00 | Truman Bulldogs v William Jewell College Cardinals | L | 52-0 |
| NCAAF | 2022/09/24 18:00 | McKendree v Walsh U. Cavaliers | W | 46-10 |
| NCAAF | 2022/09/17 22:00 | Lake Erie v McKendree | W | 37-38 |
| NCAAF | 2022/09/10 18:00 | McKendree v Delta State | L | 34-58 |
| NCAAF | 2022/09/01 23:00 | Northern Michigan Wildcats v McKendree | W | 24-31 |
| NCAAF | 2021/11/13 19:00 | Lindenwood v McKendree | L | 45-30 |
| NCAAF | 2021/11/06 18:00 | McKendree v Truman Bulldogs | L | 13-44 |
| NCAAF | 2021/10/30 18:00 | Southwest Baptist University Bearcats v McKendree | W | 42-45 |
| NCAAF | 2021/10/23 18:00 | McKendree v Missouri S&t Miners | L | 31-37 |