[10] East Carolina 48-28 South Florida [6] 2022-10-01 18:30
Stadium: FAU Stadium Round: 1
Home Manager: Jeff Scott Away Manager: Mike Houston
Head to Head
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | W | 14-29 |
| NCAAF | 2020/10/10 23:00 | East Carolina v South Florida | W | 44-24 |
| NCAAF | 2019/10/26 19:45 | South Florida v East Carolina | L | 45-20 |
| NCAAF | 2018/09/23 00:00 | East Carolina v South Florida | L | 13-20 |
| NCAAF | 2017/09/30 16:00 | East Carolina v South Florida | L | 31-61 |
| NCAAF | 2016/10/08 16:00 | South Florida v East Carolina | L | 38-22 |
| NCAAF | 2015/11/08 00:30 | East Carolina v South Florida | L | 17-22 |
| NCAAF | 2014/10/11 23:00 | South Florida v East Carolina | W | 17-28 |
Home History
| NCAAF | 2022/09/24 22:00 | Navy v East Carolina | L | 23-20 |
| NCAAF | 2022/09/17 22:00 | Campbell v East Carolina | W | 10-49 |
| NCAAF | 2022/09/10 22:00 | Old Dominion v East Carolina | W | 21-39 |
| NCAAF | 2022/09/03 16:00 | NC State v East Carolina | L | 21-20 |
| NCAAF | 2021/11/26 20:30 | Cincinnati v East Carolina | L | 35-13 |
| NCAAF | 2021/11/20 20:30 | East Carolina v Navy | W | 38-35 |
| NCAAF | 2021/11/13 17:00 | East Carolina v Memphis | W | 30-29 |
| NCAAF | 2021/11/06 19:00 | Temple v East Carolina | W | 3-45 |
Away History
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | L | 3-41 |
| NCAAF | 2022/09/17 23:30 | South Florida v Florida | L | 28-31 |
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | W | 20-42 |
| NCAAF | 2022/09/03 20:00 | BYU v South Florida | L | 50-21 |
| NCAAF | 2021/11/26 20:30 | South Florida v Central Florida | L | 13-17 |
| NCAAF | 2021/11/20 17:00 | South Florida v Tulane | L | 14-45 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | L | 45-28 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |