| Colombia Regional League | 2022/10/04 17:00 | Medellin City FC v Politecnico J.I.C. | W | 3-0 |
| Colombia Regional League | 2022/09/21 15:00 | Molino Viejo v Medellin City FC | L | 3-0 |
| Colombia Regional League | 2022/09/07 17:00 | Sol de Oriente v Medellin City FC | L | 2-1 |
| Colombia Regional League | 2022/08/30 15:00 | Medellin City FC v FC Leones Reserves | W | 4-0 |
| Colombia Regional League | 2022/08/15 15:13 | Real Santuario v Medellin City FC | L | 4-0 |
| Colombia Regional League | 2022/08/02 19:17 | Medellin City FC v Universidad de Antioquia | L | 0-1 |
| Colombia Regional League | 2022/07/11 16:00 | CD Gallegol v Medellin City FC | W | 2-4 |
| Colombia Regional League | 2022/07/05 15:23 | Medellin City FC v E.D.P IND. Medellin | W | 4-1 |
| Colombia Regional League | 2022/10/11 17:00 | Envigado FC Reserves v Molino Viejo | L | 0-2 |
| Colombia Regional League | 2022/10/04 16:43 | Total Soccer FC v Envigado FC Reserves | W | 1-3 |
| Colombia Regional League | 2022/07/27 13:13 | Envigado FC Reserves v Sellos Colombianos | W | 3-2 |
| Colombia Regional League | 2022/07/12 13:12 | Envigado FC Reserves v Ferrovalvulas FC | W | 1-0 |
| Colombia Regional League | 2022/06/10 13:00 | Envigado FC Reserves v Atletico Nacional Medellin Reserves | W | 2-0 |
| Colombia Regional League | 2022/06/06 14:00 | Estudiantes de Medellin v Envigado FC Reserves | D | 0-0 |
| Colombia Regional League | 2022/05/25 17:00 | Sol de Oriente v Envigado FC Reserves | W | 0-2 |
| Colombia Regional League | 2022/05/17 13:00 | Envigado FC Reserves v FC Leones Reserves | W | 4-0 |