Head to Head
| Ghana Premier League | 2022/05/29 15:00 | Medeama SC v Asante Kotoko | L | 0-2 |
| Ghana Premier League | 2022/01/23 15:00 | Asante Kotoko v Medeama SC | L | 1-0 |
| Ghana Premier League | 2021/04/24 15:00 | Asante Kotoko v Medeama SC | W | 1-2 |
| Ghana Premier League | 2020/12/27 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2020/01/15 15:00 | Medeama SC v Asante Kotoko | W | 1-0 |
| Ghana Premier League | 2018/03/28 15:00 | Medeama SC v Asante Kotoko | W | 1-0 |
| Ghana FA Cup | 2017/10/02 15:00 | Asante Kotoko v Medeama SC | L | 1-0 |
| Ghana FA Cup | 2017/10/01 18:00 | Asante Kotoko v Medeama SC | D | 0-0 |
Home History
| Ghana Premier League | 2022/11/07 15:00 | Great Olympics v Medeama SC | L | 1-0 |
| Ghana Premier League | 2022/10/30 15:00 | Medeama SC v Aduana Stars | L | 0-1 |
| Ghana Premier League | 2022/09/26 15:00 | Berekum Chelsea v Medeama SC | L | 1-0 |
| Ghana Premier League | 2022/09/18 15:00 | Medeama SC v Real Tamale United | W | 3-2 |
| Ghana Premier League | 2022/09/11 15:00 | Legon Cities FC v Medeama SC | W | 0-1 |
| Ghana Premier League | 2022/06/19 15:00 | Dreams v Medeama SC | L | 2-0 |
| Ghana Premier League | 2022/06/12 15:00 | Medeama SC v Accra Lions FC | W | 2-1 |
| Ghana Premier League | 2022/06/05 15:00 | Elmina Sharks v Medeama SC | W | 1-3 |
Away History
| Ghana Premier League | 2022/11/06 15:00 | Asante Kotoko v Samartex | W | 2-1 |
| Ghana Premier League | 2022/11/03 15:00 | Bechem FC v Asante Kotoko | L | 2-0 |
| Ghana Premier League | 2022/10/31 18:00 | King Faisal v Asante Kotoko | W | 0-3 |
| Ghana Premier League | 2022/09/28 15:00 | Asante Kotoko v Nsoatreman FC | W | 2-1 |
| Ghana Premier League | 2022/09/25 15:00 | Asante Kotoko v Hearts of Oak | D | 1-1 |
| CAF Champions League | 2022/09/18 15:00 | Asante Kotoko v RC Kadiogo | L | 1-4 |
| CAF Champions League | 2022/09/12 16:00 | RC Kadiogo v Asante Kotoko | W | 0-1 |
| Ghana Premier League | 2022/06/18 15:00 | Accra Lions FC v Asante Kotoko | D | 1-1 |