| Colombia Regional League | 2022/04/08 15:12 | FC Leones Reserves v Universidad de Antioquia | W | 3-2 |
| Colombia Regional League | 2022/10/03 15:02 | Club Deportivo La Chalaca v FC Leones Reserves | W | 1-3 |
| Colombia Regional League | 2022/09/24 21:27 | FC Leones Reserves v E.D.P IND. Medellin | L | 0-2 |
| Colombia Regional League | 2022/09/21 17:00 | Sol de Oriente v FC Leones Reserves | L | 1-0 |
| Colombia Regional League | 2022/09/05 15:34 | FC Leones Reserves v Talento y Vida | L | 2-3 |
| Colombia Regional League | 2022/08/30 15:00 | Medellin City FC v FC Leones Reserves | L | 4-0 |
| Colombia Regional League | 2022/08/16 15:11 | FC Leones Reserves v Lula FC | L | 2-7 |
| Colombia Regional League | 2022/07/26 15:30 | FC Leones Reserves v Club Deportivo La Chalaca | L | 3-4 |
| Colombia Regional League | 2022/07/02 21:16 | Total Soccer FC v FC Leones Reserves | L | 3-2 |
| Colombia Regional League | 2022/10/17 19:37 | E.D.P IND. Medellin v Universidad de Antioquia | W | 1-2 |
| Colombia Regional League | 2022/10/12 17:00 | Universidad de Antioquia v Sol de Oriente | L | 0-2 |
| Colombia Regional League | 2022/09/19 16:23 | Universidad de Antioquia v Independiente Sabaneta | L | 1-3 |
| Colombia Regional League | 2022/08/02 19:17 | Medellin City FC v Universidad de Antioquia | W | 0-1 |
| Colombia Regional League | 2022/07/18 17:19 | Aguilas Doradas Reserves v Universidad de Antioquia | D | 1-1 |
| Colombia Regional League | 2022/05/21 17:21 | Universidad de Antioquia v Ferrovalvulas FC | L | 1-2 |
| Colombia Regional League | 2022/05/10 17:13 | Universidad de Antioquia v Atletico Nacional Medellin Reserves | L | 0-1 |
| Colombia Regional League | 2022/04/08 15:12 | FC Leones Reserves v Universidad de Antioquia | L | 3-2 |