Stadium: Bryce Jordan Center
Home Manager: Micah Shrewsberry Away Manager: Mark Prosser
| NCAAB | 2022/03/06 17:00 | Longwood v Winthrop | L | 79-58 |
| NCAAB | 2022/03/05 19:00 | Gardner Webb v Winthrop | W | 67-76 |
| NCAAB | 2022/03/04 23:00 | High Point v Winthrop | W | 51-68 |
| NCAAB | 2022/02/26 21:00 | Charleston Southern v Winthrop | W | 86-92 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | W | 59-89 |
| NCAAB | 2022/02/19 21:30 | Winthrop v UNC Asheville | W | 84-79 |
| NCAAB | 2022/02/17 00:00 | Winthrop v Gardner Webb | W | 81-70 |
| NCAAB | 2022/02/12 21:30 | Presbyterian v Winthrop | W | 61-65 |
| NCAAB | 2022/03/12 02:00 | Penn State v Purdue | L | 61-69 |
| NCAAB | 2022/03/11 01:55 | Penn State v Ohio State | W | 71-68 |
| NCAAB | 2022/03/10 01:30 | Minnesota v Penn State | W | 51-60 |
| NCAAB | 2022/03/06 17:00 | Penn State v Rutgers | L | 58-59 |
| NCAAB | 2022/03/04 00:00 | Penn State v Illinois | L | 55-60 |
| NCAAB | 2022/02/28 00:00 | Nebraska v Penn State | L | 93-70 |
| NCAAB | 2022/02/26 00:00 | Northwestern v Penn State | W | 60-67 |
| NCAAB | 2022/02/22 00:00 | Penn State v Maryland | L | 61-67 |