Stadium: Wintrust Arena
Home Manager: Tony Stubblefield Away Manager: Tavaras Hardy
| NCAAB | 2022/03/04 00:00 | Loyola Maryland v Boston U | L | 64-76 |
| NCAAB | 2022/02/26 19:00 | Loyola Maryland v American | L | 55-65 |
| NCAAB | 2022/02/24 00:00 | Loyola Maryland v Navy | L | 50-52 |
| NCAAB | 2022/02/20 22:00 | Lehigh v Loyola Maryland | W | 42-69 |
| NCAAB | 2022/02/17 00:00 | Loyola Maryland v Lafayette | L | 68-77 |
| NCAAB | 2022/02/12 22:00 | Colgate v Loyola Maryland | L | 64-56 |
| NCAAB | 2022/02/10 00:00 | Loyola Maryland v Holy Cross | L | 64-68 |
| NCAAB | 2022/02/05 22:00 | Navy v Loyola Maryland | L | 56-55 |
| NCAAB | 2022/03/10 00:00 | DePaul v St Johns | L | 73-92 |
| NCAAB | 2022/03/05 22:00 | DePaul v Connecticut | L | 68-75 |
| NCAAB | 2022/03/03 02:00 | Marquette v DePaul | W | 80-91 |
| NCAAB | 2022/02/27 22:00 | St Johns v DePaul | W | 94-99 |
| NCAAB | 2022/02/25 01:00 | DePaul v Georgetown | W | 68-65 |
| NCAAB | 2022/02/20 01:00 | DePaul v Seton Hall | L | 64-66 |
| NCAAB | 2022/02/18 03:00 | Creighton v DePaul | L | 71-59 |
| NCAAB | 2022/02/16 02:00 | Butler v DePaul | L | 73-71 |