Stadium: Hynes Athletic Center
Home Manager: Rick Pitino Away Manager: Steve Donahue
| NCAAB | 2022/03/12 19:00 | Pennsylvania v Yale | L | 61-67 |
| NCAAB | 2022/03/05 23:00 | Princeton v Pennsylvania | L | 93-70 |
| NCAAB | 2022/02/26 19:00 | Pennsylvania v Dartmouth | L | 70-84 |
| NCAAB | 2022/02/19 23:00 | Pennsylvania v Brown | W | 89-88 |
| NCAAB | 2022/02/19 00:00 | Pennsylvania v Yale | L | 72-81 |
| NCAAB | 2022/02/12 19:00 | Harvard v Pennsylvania | W | 74-82 |
| NCAAB | 2022/02/05 23:00 | Pennsylvania v Cornell | W | 73-68 |
| NCAAB | 2022/02/05 00:00 | Pennsylvania v Columbia | W | 81-66 |
| NIT | 2022/03/17 01:00 | Iona v Florida Gators | L | 74-79 |
| NCAAB | 2022/03/10 00:00 | Rider v Iona | L | 71-70 |
| NCAAB | 2022/03/05 18:00 | Quinnipiac v Iona | W | 61-79 |
| NCAAB | 2022/03/04 00:00 | Iona v Manhattan | L | 72-74 |
| NCAAB | 2022/02/27 19:00 | Iona v Rider | W | 67-61 |
| NCAAB | 2022/02/26 00:00 | Canisius v Iona | W | 65-72 |
| NCAAB | 2022/02/20 18:00 | Fairfield v Iona | W | 58-76 |
| NCAAB | 2022/02/16 00:00 | Iona v St. Peter's | W | 70-61 |