Stadium: Redbird Arena
Home Manager: Ryan Pedon Away Manager: Rob Jeter
| NCAAB | 2022/03/19 19:00 | Western Illinois v UTEP | L | 54-80 |
| NCAAB | 2022/03/07 02:30 | Western Illinois v Oral Roberts | L | 68-80 |
| NCAAB | 2022/02/26 20:00 | Denver v Western Illinois | L | 83-77 |
| NCAAB | 2022/02/25 00:00 | Nebraska Omaha v Western Illinois | W | 76-88 |
| NCAAB | 2022/02/19 22:00 | Western Illinois v South Dakota | L | 65-78 |
| NCAAB | 2022/02/18 01:00 | Western Illinois v South Dakota State | L | 66-91 |
| NCAAB | 2022/02/12 20:00 | North Dakota v Western Illinois | W | 68-70 |
| NCAAB | 2022/02/11 00:00 | North Dakota State v Western Illinois | L | 84-81 |
| NCAAB | 2022/03/04 18:00 | Illinois St v Northern Iowa | L | 65-78 |
| NCAAB | 2022/03/04 00:00 | Indiana State v Illinois St | W | 53-58 |
| NCAAB | 2022/02/26 21:00 | Indiana State v Illinois St | W | 66-86 |
| NCAAB | 2022/02/24 01:00 | Illinois St v Southern Illinois | L | 69-90 |
| NCAAB | 2022/02/22 01:00 | Loyola Chicago v Illinois St | L | 59-50 |
| NCAAB | 2022/02/19 19:00 | Illinois St v Bradley | L | 64-72 |
| NCAAB | 2022/02/16 01:00 | Northern Iowa v Illinois St | L | 72-70 |
| NCAAB | 2022/02/12 18:00 | Illinois St v Indiana State | L | 57-60 |