Stadium: Hard Rock Hotel Riviera Maya
Home Manager: Mark Prosser Away Manager: Jay Ladner
| NCAAB | 2022/11/19 00:00 | Southern Miss v Liberty | W | 76-72 |
| NCAAB | 2022/11/15 01:00 | Southern Miss v Loyola New Orleans | W | 86-62 |
| NCAAB | 2022/11/12 00:00 | Southern Miss v Vanderbilt | W | 60-48 |
| NCAAB | 2022/11/08 01:00 | William Carey v Southern Miss | W | 42-75 |
| NCAAB | 2022/03/10 02:30 | Southern Miss v Florida Atlantic | L | 59-86 |
| NCAAB | 2022/03/09 01:00 | Southern Miss v Texas San Antonio | W | 67-64 |
| NCAAB | 2022/03/05 20:00 | Charlotte U v Southern Miss | L | 70-67 |
| NCAAB | 2022/03/03 01:00 | UAB v Southern Miss | L | 81-68 |
| NCAAB | 2022/11/19 19:00 | Winthrop v Mercer | L | 68-77 |
| NCAAB | 2022/11/16 00:00 | Winthrop v Auburn | L | 65-89 |
| NCAAB | 2022/11/12 21:00 | Middle Tenn St v Winthrop | W | 68-76 |
| NCAAB | 2022/11/10 00:00 | Piedmont v Winthrop | W | 56-78 |
| NCAAB | 2022/11/08 00:00 | Winthrop v Penn State | L | 68-93 |
| NCAAB | 2022/03/06 17:00 | Longwood v Winthrop | L | 79-58 |
| NCAAB | 2022/03/05 19:00 | Gardner Webb v Winthrop | W | 67-76 |
| NCAAB | 2022/03/04 23:00 | High Point v Winthrop | W | 51-68 |