Stadium: Great Southern Bank Arena
Home Manager: Dana Ford Away Manager: Bill Walker
| NCAAB | 2021/11/17 01:00 | Bradley v Missouri S&T | L | 92-66 |
| NCAAB | 2021/02/27 20:30 | Illinois Springfield v Missouri S&T | L | 80-71 |
| NCAAB | 2021/02/26 00:30 | Lewis v Missouri S&T | L | 74-64 |
| NCAAB | 2021/02/20 20:00 | Missouri S&T v Indianapolis | L | 64-73 |
| NCAAB | 2021/02/13 21:00 | McKendree v Missouri S&T | L | 77-68 |
| NCAAB | 2021/02/06 20:00 | Missouri S&T v Lindenwood | L | 77-89 |
| NCAAB | 2021/02/05 00:30 | Missouri S&T v Maryville | L | 68-70 |
| NCAAB | 2021/01/29 00:30 | Missouri S&T v Drury | W | 67-66 |
| NIT | 2022/03/15 23:00 | Missouri State v Oklahoma | L | 72-89 |
| NCAAB | 2022/03/05 23:00 | Drake v Missouri State | L | 79-78 |
| NCAAB | 2022/03/05 00:00 | Valparaiso v Missouri State | W | 58-67 |
| NCAAB | 2022/02/26 22:00 | Missouri State v Evansville | W | 88-79 |
| NCAAB | 2022/02/24 01:00 | Bradley v Missouri State | W | 67-83 |
| NCAAB | 2022/02/20 19:00 | Missouri State v Northern Iowa | L | 75-95 |
| NCAAB | 2022/02/16 01:00 | Indiana State v Missouri State | W | 70-79 |
| NCAAB | 2022/02/12 21:00 | Valparaiso v Missouri State | W | 66-84 |